Comments on: Molecular Biology of Memory http://english.martinvarsavsky.net/general/molecular-biology-of-memory.html Blog of an entrepreneur Mon, 13 Feb 2012 19:31:49 +0000 hourly 1 http://wordpress.org/?v=3.3.1 By: 3abboud of rak http://english.martinvarsavsky.net/general/molecular-biology-of-memory.html#comment-1196 3abboud of rak Sun, 20 Aug 2006 19:43:45 +0000 http://192.168.1.2/en/?p=402#comment-1196 Kandel has done some good basic research into some pretty rudimentary memory-related behavior. but it gets much more interesting with the Drosophila memory research. You can search for articles on research on the Drosophila genes.... radish, rutabaga, dunce, amnesiac mutant genes. very fascinating stuff. also fascinating that flies can 'black out' or just plain forget stuff. Kandel has done some good basic research into some pretty rudimentary memory-related behavior. but it gets much more interesting with the Drosophila memory research. You can search for articles on research on the Drosophila genes…. radish, rutabaga, dunce, amnesiac mutant genes.

very fascinating stuff. also fascinating that flies can ‘black out’ or just plain forget stuff.

]]> By: Wilbert van den Boom http://english.martinvarsavsky.net/general/molecular-biology-of-memory.html#comment-1195 Wilbert van den Boom Thu, 17 Aug 2006 00:07:01 +0000 http://192.168.1.2/en/?p=402#comment-1195 I'm a psychologist in labour ( I don't know if that's the correct translation) and I'm doing research in the aspect of Human Resources Theory (Ideology). It's a Management theory with it's basics the idea that perfomance can be increased by guiding behavior through incentives . Totally ridiculous, but most organizations are build up by this idea. To make a long story short...I'm sorting out the origins of behavior and came to the point when or which behavior should be remembered to deal with the environment......in short...how exactly does that memory function. As far as I can see know it's likely the strenght and number of synapses. It's just like the grow of a muscle......to grow it needs proteÏn, so it has much more to do with the cAMP/PKA system (?)within the neuron. So short term memory is more likely the cells with little cAAMP/PKA system and long term meomory with advanced cAMP/PKA (?)...which I'm still sorting out. The prediction as mentioned above is based on what's memorized. When actual outcome differs from the predicted outcome, the result is a prediction error. This prediction error signal can be used to learn correct predictions and also to learn appropriate actions and also adjust our meaning (Sinn) of complexity. The brain is a pattern-matching machine, The more associations (matches) you have for a particular memory, the more protection you have against losing it, and the more ways you will have to remember it later, the more complexity can be handled. And I absolutely don't think there is a plesure sytem in the brains through which behavior is 'guided' more likely the meaning/need which is created by the prediction (error). Only pleasure would restrict the the human adaption to the ever developing environment. If environment gets complex the inner has to be as much complex (Ashbey's law) ......adaptation to the environment is only possible when mankind expands meaning, expands neurological possiblities, expands memory, expands neurons. by he way the url is of my site as a bagpiper, but interesting though I’m a psychologist in labour ( I don’t know if that’s the correct translation) and I’m doing research in the aspect of Human Resources Theory (Ideology). It’s a Management theory with it’s basics the idea that perfomance can be increased by guiding behavior through incentives . Totally ridiculous, but most organizations are build up by this idea. To make a long story short…I’m sorting out the origins of behavior and came to the point when or which behavior should be remembered to deal with the environment……in short…how exactly does that memory function.
As far as I can see know it’s likely the strenght and number of synapses. It’s just like the grow of a muscle……to grow it needs proteÏn, so it has much more to do with the cAMP/PKA system (?)within the neuron. So short term memory is more likely the cells with little cAAMP/PKA system and long term meomory with advanced cAMP/PKA (?)…which I’m still sorting out.
The prediction as mentioned above is based on what’s memorized. When actual outcome differs from the predicted outcome, the result is a prediction error. This prediction error signal can be used to learn correct predictions and also to learn appropriate actions and also adjust our meaning (Sinn) of complexity. The brain is a pattern-matching machine, The more associations (matches) you have for a particular memory, the more protection you have against losing it, and the more ways you will have to remember it later, the more complexity can be handled.
And I absolutely don’t think there is a plesure sytem in the brains through which behavior is ‘guided’ more likely the meaning/need which is created by the prediction (error). Only pleasure would restrict the the human adaption to the ever developing environment. If environment gets complex the inner has to be as much complex (Ashbey’s law) ……adaptation to the environment is only possible when mankind expands meaning, expands neurological possiblities, expands memory, expands neurons.

by he way the url is of my site as a bagpiper, but interesting though

]]> By: Juanma Schvartman http://english.martinvarsavsky.net/general/molecular-biology-of-memory.html#comment-1194 Juanma Schvartman Sun, 06 Aug 2006 20:41:34 +0000 http://192.168.1.2/en/?p=402#comment-1194 I somehow stumbled upon your blog partly via looking for an article by a crazy Uruguayan you may know. In any case, I could not agree more about the state at which the study of memory is at today. I suggest you have a look (and listen) at the BBC Reith Lecture Series of 2003, given by Vilayanur Ramachandran, who studies cognitive neurobiology in San Diego. His talks are enjoyable, deep and laugh out loud funny. He was very much in touch with Crick before he died and has explored a number of psychological dilemas from the point of view of the biologist. Here is the link: <a href="http://www.bbc.co.uk/radio4/reith2003/" rel="nofollow">http://www.bbc.co.uk/radio4/reith2003/</a> Crick also has a book that deals with how to study the brain from the point of view of molecular biology and neuroscience: The Astonishing Hypothesis. I somehow stumbled upon your blog partly via looking for an article by a crazy Uruguayan you may know. In any case, I could not agree more about the state at which the study of memory is at today. I suggest you have a look (and listen) at the BBC Reith Lecture Series of 2003, given by Vilayanur Ramachandran, who studies cognitive neurobiology in San Diego. His talks are enjoyable, deep and laugh out loud funny. He was very much in touch with Crick before he died and has explored a number of psychological dilemas from the point of view of the biologist. Here is the link: http://www.bbc.co.uk/radio4/reith2003/

Crick also has a book that deals with how to study the brain from the point of view of molecular biology and neuroscience: The Astonishing Hypothesis.

]]> By: Oliver Thylmann http://english.martinvarsavsky.net/general/molecular-biology-of-memory.html#comment-1193 Oliver Thylmann Sat, 05 Aug 2006 16:51:57 +0000 http://192.168.1.2/en/?p=402#comment-1193 I suggest you read the book On Intelligence (http://www.onintelligence.org/) by Jeff Hawkins among others. He was one of the founders of Palm and Handspring. He has now founded Numenta (http://www.numenta.com/) to get deeper into the ideas behind his book. The general idea is that we form things in our brain based on experience (call it synapsis, whatever) and our brain is constantly in prediction mode. The more experience we gain, the sooner the brain can make an accurate prediction. If you grab a bottle, you will only really "think" if there is something that happens where the prediction your brain takes is different from what your senses tell you. Ok, very simplistic now. But reading the book was great and I think there is some very good potential in the ideas he presents. I suggest you read the book On Intelligence (http://www.onintelligence.org/) by Jeff Hawkins among others. He was one of the founders of Palm and Handspring. He has now founded Numenta (http://www.numenta.com/) to get deeper into the ideas behind his book.

The general idea is that we form things in our brain based on experience (call it synapsis, whatever) and our brain is constantly in prediction mode. The more experience we gain, the sooner the brain can make an accurate prediction. If you grab a bottle, you will only really “think” if there is something that happens where the prediction your brain takes is different from what your senses tell you.

Ok, very simplistic now. But reading the book was great and I think there is some very good potential in the ideas he presents.

]]> By: Antoin O Lachtnain http://english.martinvarsavsky.net/general/molecular-biology-of-memory.html#comment-1192 Antoin O Lachtnain Sat, 05 Aug 2006 15:20:25 +0000 http://192.168.1.2/en/?p=402#comment-1192 Not a lot is certain about memory, but one thing is: there is a complex mechanism to memory, rather than just a 'locus' where facts are stored. Retrieval, indexing and Storage are just as important as the actual 'repository' where the memory is stored. You can't really understand memory in terms of the repository alone. Things like facts seem to start in short term memory and make their way to long-term memory. Things like physical skills seem to be stored in a different way to things that happen to us ('episodic memory'). Facial recognition is tied to particular areas of the brain. There are probably a lot of different mechanisms involved, even though we call the whole thing 'memory' as if it was a unitary phenomenon. Not a lot is certain about memory, but one thing is: there is a complex mechanism to memory, rather than just a ‘locus’ where facts are stored. Retrieval, indexing and Storage are just as important as the actual ‘repository’ where the memory is stored. You can’t really understand memory in terms of the repository alone. Things like facts seem to start in short term memory and make their way to long-term memory. Things like physical skills seem to be stored in a different way to things that happen to us (‘episodic memory’). Facial recognition is tied to particular areas of the brain. There are probably a lot of different mechanisms involved, even though we call the whole thing ‘memory’ as if it was a unitary phenomenon.

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